منابع مشابه
Temozolomide in Pediatric Cns Tumours
Temozolomide (tmz) is an oral alkylating agent that received accelerated approval from the U.S. Food and Drug Administration in 1999 because of its promising activity in high-grade glioma (hgg) in adults. A European Organisation for Research and Treatment of Cancer randomized trial eventually confirmed a significant survival benefit in adults with newly diagnosed glioblastoma multiforme when tm...
متن کاملPlatinum-based chemotherapy for recurrent CNS tumours in young patients.
Twenty nine patients (median age 12 years) with a CNS tumour, received platinum-based chemotherapy for assessable disease. In 23 patients there was an objective response with improvement lasting for a median duration of 11 months. There was little difference in the response to cisplatinum or carboplatin therapy. The response rates in specific disease groups were: medulloblastoma 8/10, two with ...
متن کاملThe prognostic role of proliferation activity in human CNS tumours: the determination of AgNOR, PCNA and Ki-67 expression. Part 1: AgNOR expression in CNS tumours.
The aim of the study was an evaluation of the proliferation activity of Central Nervous System tumours by using silver colloid staining of nucleolar organiser regions (AgNORs) and comparing the results with the proliferation activity estimated by using PCNA and Ki-67 antibodies to clarify the clinicopathological significance of this method. The first part of the study describes the results of A...
متن کاملElimination of proliferating cells from CNS grafts using a Ki67 promoter-driven thymidine kinase
Pluripotent stem cell (PSC)-based cell therapy is an attractive concept for neurodegenerative diseases, but can lead to tumor formation. This is particularly relevant as proliferating neural precursors rather than postmitotic mature neurons need to be transplanted. Thus, safety mechanisms to eliminate proliferating cells are needed. Here, we propose a suicide gene approach, based on cell cycle-...
متن کاملImmunohistochemistry of a proliferation marker Ki67/MIB1 in adrenocortical carcinomas: Ki67/MIB1 labeling index is a predictor for recurrence of adrenocortical carcinomas.
Adrenocortical carcinoma (ACC) is a rare, highly malignant tumor. The aim of the present study is to evaluate the prognostic relevance of a proliferation marker Ki67/MIB1 by immunohistochemistry in 17 cases who underwent resections of the primary tumors and diagnosed to have ACC at Tohoku University Hospital based on the criteria of Weiss during the period from 1976 to 2005. The follow-up perio...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Indian Journal of Pathology and Oncology
سال: 2019
ISSN: 2394-6784,2394-6792
DOI: 10.18231/j.ijpo.2019.114